Optimization of proton therapy eye-treatment systems toward improved clinical performances

The treatment protocols of cancerous ocular diseases with proton therapy are well established, and dedicated eye-treatment systems can produce the clinical beam properties that meet peculiar features required by modalities. However, for general-purpose multiroom comprising beamlines nozzles, design commissioning procedures must be optimized to achieve performances fully in terms depth-dose distal falloff, lateral penumbra, dose rate. This paper presents a realistic start-to-end transport particle-matter interactions model ion applications Proteus\textregistered{} Plus $(\mathrm{P}+)$ single-scattering room Beam Delivery SIMulation (bdsim) using Geant4. is used establish optimization patterns optics smaller falloff than baseline while maintaining nominal rate flatness deposition profile. An alternative proposed increase further up factor 3, allowing delivering complete hypofractionated session under 60 s. It uses beam-stopping device complement existing scattering nozzle. in-depth study system performed bdsim numerical simulations discussed detail.